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E., Deciphering Nociplastic Pain: Clinical Features, Risk Factors and Potential Mechanisms, Nature Reviews Neurology 20, no

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There are also reports that rupture of the respiratory or intestinal epithelial barrier and weakening of other barriers, for example, the bloodbrain barrier or the vascular endothelial barrier, may facilitate the development of metabolic and autoimmune diseases [55, 81,82,83,84]
