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Macrophage-derived MMP12 promotes fibrosis through sustained damage to endothelial cells

the PYD domain of ASC interacts with the PYD of inflammasomes, and its caspase activation domain and CARD domain interact with the CARD of Caspase-1 to form the NLRP3 complex

Traditional pharmacotherapy for drug delivery to the lungs can be classified according to the type of therapeutic agents [10, 11]

When the two enzymes concentrations were equal, the GSSG levels were depleted more quickly than in the standard model, while the H 2 O 2 concentration decreased far more slowly than in the standard model

Lastly, in contrast to GLO1, we found GLO2 protein levels to be downregulated and its precursor sLG to be upregulated by hypoxia in lung cancer cells, suggesting that hypoxic cells need to detoxify MG either by alternative routes 47,70 or perhaps they rather accumulate the nontoxic intermediate sLG than producing higher levels of D-lactate, which would further increase acidification next to the already upregulated anaerobic L-lactate production from pyruvate