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A technique that provides true randomisation (such as a computerised sequence generator) is recommended, as treatment allocation cannot then be predicted, whereas the use of information such as date of birth to approximate randomisation may lead to selection bias and is therefore not acceptable [15, 17]

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One important application for the excretion of alcohol in the breath is that given the high blood flow of the lungs, end-expiratory breath alcohol concentration closely follows arterial blood alcohol concentration (see (100) as an example), which allowed the development of the breathalyzer to non-invasively estimate brain and blood alcohol concentrations

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Substances already found in the food supply are also generally considered fair game for inclusion in supplements