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Determination of trimethylamine-N-oxide in combination with l-carnitine and -butyrobetaine in human plasma by UPLC/MS/MS
Jan 1 2023;320:169-177
Physicochemical attributes of RNA-LNPs The physicochemical attributes of LNPs are crucial in determining their stability and functionality, directly influencing in vivo fate and gene delivery efficiency [55]
Furthermore, protein binding, tissue distribution, metabolic conjugation, and elimination kinetics further influence biologically active free drug levels
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