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Currently, at least two mechanisms have been described by which GSSG concentration or the GSH status can modulate the activity of signaling proteins independently of ROS

The mice were then randomly divided into five groups, namely, the Prdx2 +/+ (wild) control mice, Prdx2 / (knockout) control mice, Prdx2 +/+ mice treated with Imiquimod (IMQ), Prdx2 / mice treated with IMQ, and Prdx2 +/+ as well as Prdx2 / mice treated with Conoidin A and IMQ

Ferroptosis differs from other forms of cell death in that morphologically, it typically manifests as increased cell volume, mitochondrial swelling and endoplasmic reticulum expansion (13)

Neurotoxicity Research, 35 (1), 255259

doi: 10.1038/s41580-019-0151-1 66 ChenX-YZhangJZhuJ-S
