glutathione-related antioxidant defense system Pathway of and oxidative stress mechanisms The thiol-based mechanism of antioxidant

For an extended discussion of the roles of these proteins, see publication: (Sen and Imlay, 2021)

Suda A, Umaru BA, Yamamoto Y, Shima H, Saiki Y, Pan Y, et al

The effects of nutlin-3 were dose-dependent, with increasing concentrations of this inhibitor resulting in greater p53 stabilization, which correlated with increased induction of the p53 target genes CDKN1A and HDM2 and greater suppression of erastin2-induced ferroptosis (Fig S1AD)

Additionally, NAC reduced apoptotic signaling (including cytochrome c release and caspases 3/9) and neuroinflammation (as indicated by CD11b expression)

Recurrent outbreaks are usually less severe and shorter than the first outbreak