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Surprisingly, the deletion of HIF2 also led to enhanced tumor growth and accelerated tumor progression
Bourchis, D., Xu, G
Helicobacter 4 : 7-16
[DOI] [PMC free article] [PubMed] [Google Scholar] 173.Che X., Roy A., Bresnahan M., Mjaaland S., Reichborn-Kjennerud T., Magnus P., Stoltenberg C., Shang Y., Zhang K., Susser E., et al
mTORC1 activates the transcription factor ATF4, which in turn upregulates MTHFD2, a mitochondrial enzyme involved in the tetrahydrofolate cycle that contributes to de novo purine synthesis
