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The liver can produce scar tissue where it is damaged, leading to a thickening of the tissue called fibrosis

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These proteins are: horse heart apocytochrome c (Stellwagen et al., 1972), protein phosphatase inhibitor-1 from rabbit skeletal muscle (19.2 kDa by sedimentation and 60.0 kDa by gel-filtration) (Nimmo and Cohen, 1978), a dopamine-and adenosine 3:5-monophosphate-regulated phosphoprotein from bovine caudate nucleus, DARPP-32 (27.6 kDa by sedimentation and 59 kDa by gel-filtration) (Hemmings et al., 1984), bovine cardiac troponin C in the absence of calcium (McCubbin and Kay, 1985), heat-stable microtubule-associated protein MAP2 (Hernandez et al., 1986), smooth muscle caldesmon (Lynch et al., 1987), brain-specific 14-kDa protein (14 kDa by Sodium Dodecyl Sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and 57 kDa by gel filtration) (Nakajo et al., 1990), carboxyl-terminal transactivation domain of Vmw65 from herpes simplex virus type 1 (11.0 kDa from sedimentation and 55.0 kDa from gel-filtration) (Donaldson and Capone, 1992), prothymosin (Stokes radius is 1.77 larger than those expected for a compactly folded protein consisting of 109 amino acid residues) (Gast et al., 1995), chromogranin B (100 kDa by SDS-PAGE and 220 kDa by gel-filtration) (Yoo, 1995), human topoisomerase I (66 kDa by sedimentation and 300 kDa by gel-filtration) (Stewart et al., 1996), N-terminal domain of human topoisomerase I (198 residues, 66 kDa by sedimentation and 96 kDa by gel filtration) (Stewart et al., 1996), oncoprotein 18 (Op18)/stathmin from fetal calf thymus (17.22 kDa by mass-spectrometry and 64 kDa by gel-filtration) (Schubart et al., 1987

A-R, Banach M, et al

Surgical procedures Sometimes few surgeries that involve the removal or alteration of the stomach or intestines can affect the bodys ability to absorb vitamin B12 as removal reduces the surface area available for absorption