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Amphetamine-based drugs showed slightly higher effect sizes overall, but the review also documented higher rates of side effects with amphetamines compared to methylphenidate

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However, its immunomodulatory properties and potential cardiovascular toxicity have constrained clinical development, highlighting the challenges of translating promising preclinical findings into safe and effective patient therapies (179, 183)

A primary way to elevate the extracellular Na + content is to increase the activity of the Na + /K + pump (24)