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GENERAL SIGNIFICANCE GSH is a key antioxidant that also modulates diverse cellular processes

This is particularly relevant in obesity, where exercise adherence is already challenged by musculoskeletal discomfort and low baseline fitness

By degrading the target, PROTAC 19 reduces AKT protein phosphorylation and leads to increased p53 expression 81

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On the other hand, inflammatory mediators can increase mucosal permeability and influence gut microbiota
