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The updates on hypersensitivity reactions are related to dermatologic adverse effects and angioedema, as follows: Serious dermatologic reactions that have been reported with valproate treatment include toxic epidermal necrolysis (TEN), Stevens Johnson syndrome (SJS), acute generalized exanthematous pustulosis (AGEP), and erythema multiforme (EM)

Metabolism: clinical and experimental , 46 (1), 8996

They also improved hepatic histology, reducing ballooning, inflammatory infiltration, and lipid droplet accumulation (78)

Immunology 129(4):525535

FIGURE 3 The relationship between oxidative stress and DNP, development, and progression requires further elucidation by exploring the detection of biomarkers (Hirao et al., 2010