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Differential methylation, particularly in relation to active demethylation pathways, and expression patterns of genes regulating lipid metabolism, inflammation, and fibrosis appear to be closely linked to the development and exacerbation of MASLD, from steatosis to more severe forms such as MASH and fibrosis [335, 336]

Thorac Surg

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Furthermore, formation of Cr-Asc (Ascorbate), Cr-GSH, and Cr-cys (cysteine) crosslinks depletes cellular antioxidants and induces oxidative stress (Yao et al., 2008)

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