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(1994) deduced the amino acid sequence for rat kidney KAT I from the cDNA and expressed the enzyme in COS-1 cells

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When Mg2+ was administered combined with vitamins A, C, and E there was a substantial protective effect reflected in increased hair cell survival and decreased auditory threshold shifts (Le Prell et al., 2+ plus vitamins A, C and E partially recovers PTS, along with a significant reduction of type II fibrocytes in the cochlear lateral wall (Le Prell et al., 2+ significantly reduced PTS (Attias et al., 2+ is well-tolerated although there are some dose-dependent side effects such as nausea, diarrhea, stomachache, headache, tinnitus, and dizziness, which appear when used at high concentrations (Attias et al., Conclusions In light of new evidence about the etiopathogenic and pathophysiological mechanisms underlying NIHL, it becomes a priority to develop new therapeutic strategies that help to improve the quality of life of millions of people affected by this condition