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There are several reasons why glutathione levels can decrease, such as: Ageing (6) Chronic stress (7) Poor diet (8) Its thought that exposure to pollution, chemicals, and ultra-processed foods can also increase oxidative stress, using up glutathione faster

10.1038/s41467-020-20141-z 66

10.1016/j.chmed.2021.09.001 220 ZhaoR.LiuW.WangM.ZhangY.PanL.FengF.et al (2020)

The 7nACh receptors are also expressed in astrocytes and are linked to generation of Ca 2+ signals 553

The presence of ubiquitin within these structures suggests a build-up of proteins that were directed towards proteolytic degradation
