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In this 2008 study, intrathecal (i.t.) administration of ALX5407 (doses of 10, 50, and 100 g) resulted in significant analgesic effects, with an increase in mechanical pain thresholds observed up to 240 min after administration

Its typically part of a broader hormone optimization plan, tailored to the individuals age, symptoms, and health goals

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Van Vuuren et al., 2015)

Accordingly, despite losing 25% of their body mass, GLP-1MK-801-treated mice maintained an energy expenditure that was similar to that of vehicle-treated control mice and was therefore also significantly higher than the gradually decreasing energy expenditure observed in mice that were calorie-restricted to match the weight loss trajectory of GLP-1MK-801-treated mice