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Based on the intrinsic physicochemical properties of NPs, we provide a nanotherapy strategy targeting CAFs to significantly inhibit CRC growth by not only inducing ferroptosis of CAFs, thereby reducing pro-tumorigenic paracrine signaling, but also remodeling the TME, and alleviating CAF-mediated immunosuppression

Acting like ghrelin, ipamorelin stimulates the release of growth hormone-releasing hormone and reduces the release of somatostatin

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4 , 278286, doi: 10.1038/nchembio.85 (2008)

Developing novel applications of mycelium-based biocomposite materials for design and architecture