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There are relatively few approaches for disentangling truly dysfunctional protein processing from the criteria by which the UPR perceives ER stress, which are still not well understood

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Regulation of Stress Response: Chronic stress can significantly impact mood and behavior

This section focuses on disease-modifying strategies based on non-dopaminergic mechanisms, encompassing multiple directions such as regulation of protein homeostasis, restoration of brain iron metabolism balance, suppression of neuroinflammation, and improvement of energy metabolism

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