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doi: 10.1016/j.redox.2014.03.002

The most significant manifestations expressed by this disease can be attributed to the predominant cytokine storm syndrome in the lungs, resulting in severe oxidative stress, exacerbated inflammation and alveolar injury

In brief, pro-inflammatory cytokines seem to damp several components of the IGF-I pathway

This research could contribute towards new diagnostic biomarkers and therapies focusing on ion channel dysfunction or calcium signalling, Professor Marshall-Gradisnik said

Relative gene expression was calculated using the 2Cq method and normalized to -actin, based on the equation from Livak and Schmittgen (27)