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Peer-review started: August 28, 2018 First decision: October 9, 2018 Article in press: November 2, 2018 P- Reviewer: Kan L, Marcos M, Polonikov AV, Yu XJ S- Editor: Wang XJ L- Editor: A E- Editor: Yin SY Contributor Information Luciana Moine, Laboratorio Dr

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Since members of the glucose transporter (GLUT) family, such as GLUT1 and GLUT3, are widely expressed in normal tissues, including the brain and red blood cells, non-selective inhibition of their activities can lead to systemic hypoglycemia and tissue energy depletion

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