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It is speculated that HCV, by damaging liver, may promote systemic oxidative stress in part by disruption of GSH export
In erythrocytes, if the PPP does not function, then the (RBC) oxidative stress will lead to lysis , anemia
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GSR activity is also NADPH-dependent, connecting glutathione recycling to the pentose phosphate pathway (G6PD activity) and the NADPH-generating capacity of the cell
