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J Biol Chem 284:2659126602

The activity of several protein kinases, and particularly of protein kinase C (PKC) sub-family members can be modulated in human neuronal cells supplemented with tocopherols and tocotrienols (Galli et al., 2017)

The removal of extracellular serine using a serine-restricted diet inhibits the antibacterial response of CD8 + T cells [263]

The ubiquitin-conjugating enzyme E2N (UBE2N) is overexpressed in various cancers and promotes breast cancer metastasis to the lung by activating TGF-mediated signaling pathways

Metformin, a widely used therapeutic in PCOS, has been repeatedly demonstrated to remodel mitochondrial morphology and suppress ROS production via mTOR-dependent and miRNA-mediated pathways (e.g., miR-670-3p/NOX2) [102,123,124]