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In studies of atherosclerosis, ATOX1 is increased in the intima of atherosclerotic lesions in ApoE / mice and is localized to the nucleus under pathological conditions, including hypertensive and atherosclerotic vessels ( 6.3 Copper ionophores Copper ionophores represent another therapeutic strategy for modulating copper levels and influencing related cellular pathways in HF

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The anti-inflammatory actions of GCs are mediated through transrepression , a process in which the ligand-activated GR, often as a monomer, interacts with and inhibits the activity of pro-inflammatory transcription factors, such as nuclear factor-kappa B (NF-B) and activator protein-1 [23]

Jiang S, Wang Y, Zhang X

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