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(Springer)The adult quiescent blood-brain barrier (BBB), a structure organized by endothelial cells through interactions with pericytes, astrocytes, neurons and microglia in the neurovascular unit, is highly regulated but fragile at the same time

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Upon activation, microglia upregulate NADPH oxidase 2 which produces superoxide and inducible nitric oxide synthase, ultimately generating nitric oxide

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