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In human studies there is a range of 241,206 mg vitamin E/day with no adverse effects

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In addition to the above PTT, NBNs are also used in photodynamic therapy (PDT) through intravenous injection

Currently undergoing Phase 1 clinical trial evaluation (ClinicalTrials.gov Identifier: NCT04167137) in patients with advanced solid tumors and lymphomas, the engineered bacterial strain SYNB1891 represents a novel approach to targeting the tumor microenvironment