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After KD uptake, the recorded reduction in AST and ALT activities, as compared to STZ + HFD, is still significantly higher than the control

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Ischemic optic neuropathies: current concepts

proposed a vascular normalization theory in which a judicious intensity of anti-angiogenic therapy could result in an equilibrium between anti-angiogenic and pro-angiogenic signals within the TMEvascular normalization statusand enable efficient delivery of oxygen, drugs, and anti-cancer immune cells into the tumor, rather than inducing excessive destruction of vessels and intratumoral hypoxia 35,36