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Within the same synthetic pathways for GSH production, adequate levels of several B vitamins are essential, as they serve as enzymatic cofactors in multiple metabolic pathways contributing to GSH synthesis: (i) vitamin B6 contributes to normal cysteine synthesis, regarded as the rate-limiting factor in GSH synthesis

10.1083/jcb.74.1.68 13 BettegowdaA.WilkinsonM

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In the context of viral replication, constraint-based modeling allows the simulation and prediction of the viral capacity to replicate within a host cell by considering nutrient availability, energy resources, and other cellular factors 16,17

By preventing the ubiquitination-mediated degradation of IB, curcumin blocks the nuclear translocation of NF-B and inhibits the production of proinflammatory cytokines, ultimately suppressing cancer cell proliferation and metastasis (Wang et al., 2024)