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When considering the interaction between loss of pink-1 and metabolite addition, these mutant lines confirm RNAi results, suggesting epistatic regulation of metabolite activity by loss of pink-1 (Figures 4d and e) but not pdr-1, which appears to acts in parallel to metabolite toxicity

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Result Repeated intraperitoneal injections of nitroglycerin induced migraine-like behavior in mice Based on previous reports, we established a chronic migraine-like model in male mice by administering intraperitoneal injections of nitroglycerin at a dose of 10 mg/kg every other day(Fig

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