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Metabolite set enrichment analysis (MSEA) was conducted to identify pathways associated with the observed metabolite changes (Fig

[DOI] [PMC free article] [PubMed] [Google Scholar] 279.Lian F, Jin D, Bao Q, Zhao Y, Tong X

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In patients with MMA two main pathologies have been reported, chronic tubulo-interstitial nephritis [49], and renal tubular acidosis [254],[255]

These can include: learning problems or intellectual disabilities delays in walking and motor skills abnormal involuntary movements ( dystonia and chorea ) rigid muscle tone, called spasticity poor growth with short stature skin rashes and infections osteoporosis enlarged liver kidney disease or failure vision loss due to problems with the nerves in the eye Without treatment, brain and nerve damage can occur