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Such long-lasting phenotypic changes, however, can only be sustained when an epigenetic stabilization of gene transcription or programming occurs in the cell population that is capable of self-renewing, is multipotent, and is required in organ development and regeneration [41, 131]
USP Chapter : Validation of Compendial Procedures
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[15] When Waddington coined the term, the physical nature of genes and their role in heredity was not known
Perlmutter is a Clinical Instructor in Orthopaedic Surgery at Harvard Medical School
