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Migraine headache rates in the combined Depakote 1,000/1,500 mg group were significantly lower than in the placebo group

40 reported that, in first-episode bipolar patients randomized to a year of lithium or quetiapine, those on lithium did better in every respect: fewer episodes of mania and depression, better functioning and cognition, and fewer abnormalities on brain imaging

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Choucair F, Saliba E, Jaoude IA, Hazzouri M