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Description
P., Gaston, F., Kochunov, P., & Hong, L
Glutathione is considered the body's master antioxidant
For example, platinum (IV) prodrugs activated by intracellular GSH have demonstrated enhanced tumor selectivity and reduced systemic toxicity in clinical trials
Pujol-Autonell I, Mansilla MJ, Rodriguez-Fernandez S, Cano-Sarabia M, Navarro-Barriuso J, Ampudia RM, Rius A, Garcia-Jimeno S, Perna-Barrull D, Martinez-Caceres E, Maspoch D, Vives-Pi M
This is in part established by glutathione, a redox-active metabolite present in reduced (GSH) and oxidized (GSSG) forms
