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These initially compensatory mechanisms eventually become maldaptive, resulting in CHF and/or forward heart failure

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pmid:12775338 Rhee SG (2001) Regulation of phosphoinositide-specific phospholipase C

Lastly, the interplay between Nf-B and Nrf2 pathways significantly influences the progression of long-term COVID neuropsychiatric complications [200-202], and astrocyte-neuron communication via the astroglial xc-system is crucial for synaptic glutamatergic regulation [203]

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