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When administered in combination with paclitaxel, quercetin synergistically promotes apoptosis and inhibits survival pathways, including PI3K/Akt, STAT3, and NF-B, leading to enhanced cytotoxicity with a potentially reduced drug dosage and systemic toxicity (Silva-Pinto et al., 2025)

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Deletion of GRP78 from CTL also displayed lowered granzyme B secretion and compromised cytotoxic potential

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