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In terms of lung microbiota function, the abundance of proteins in four signaling pathways, the Wnt, Notch, chronic myeloid leukemia signaling pathway, and mitogen-activated protein kinase signaling pathway-yeast (KO04011), was significantly negatively correlated with serum IL-1 and IL-10 levels, suggesting an association between lung microbiota and the pathogenesis of ALI/ARDS

B., Alves, M

Brain activity profiling of GLP-1MK-801 Encouraged by the transcriptomic data indicating that the weight loss is evoked through a mechanism of action involving the combined pharmacological actions of NMDA receptor antagonism and GLP-1 receptor agonism in the hypothalamus, we performed a comprehensive comparison between GLP-1MK-801 and the long-acting GLP-1 receptor agonist, semaglutide

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345 The expression of both autophagic and lysosomal components decreases with age, and disruption of autophagy and endocytosis causes neurodegeneration in mouse models, suggesting a possible explanation for the age dependency of this group of diseases