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Primary-progressive MS (PPMS) is characterized by a linear worsening of symptoms from disease onset [7] and given that the bloodbrain barrier (BBB) is mostly intact, CNS/cerebrospinal fluid -localized mechanisms likely facilitate demyelination [8, 9]

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Should I increase the dose or frequency of monthly 1000mg (milligrams) vitamin B12 injections for a patient with persistent low vitamin B12 levels?

Data Availability Statement The data presented in this study are available on request from the corresponding author.

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