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Substance P (SP), a member of the tachykinin neuropeptide family widely distributed in central and peripheral nervous system, and produced also by lymphocytes, macrophages, neutrophils, and dendritic cells, has a role in pain, inflammation, and fibrosis

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Cardiotoxicity attenuation has been studied in the context of bupivacaine exposure (PMID 27815173), broadening the literature beyond the conventional musculoskeletal and gastric framings