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2,97 Studies and clinical practice of treatment of pernicious anaemia with regular high-dose injections has confirmed the safety of B12 at high dosages, and therefore neither the Institute of Medicine (IOM) in the USA nor the European Food Safety Agency (EFSA) have set an upper limit

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When binding contribution of the CPP is ignored, the native FOXO4 sequence in the DRI isoform would in fact be lower than the CPP fused form (-106.90 kcal.mol 1 )

Extrapolating this to a 70kg human using the standard FDA allometric scaling factor (dividing by 6.2) suggests a human-equivalent dose of approximately 8mg/kg, or 560mg daily

P., Fruchard, J