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Description
[DOI] [PubMed] [Google Scholar] 85.Hovaguimian, A
These cells are macrophage-like cells and are involved in the brains innate immune system, whose defense mechanisms are altered in neurodegenerative diseases such as AD (26)
This pathway is considered to be neuroprotective as it can provide pyruvate when glycolysis is inhibited [115117]
As the disease progresses however it becomes increasingly non-responsive to therapeutic interventions [92, 93]
(b) Beta oxidation in the mitochondria (40%) This may deplete intracellular acetyl-CoA, so its not fantastic
