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In two of the studies, nerve conduction velocities were evaluated using standard techniques, as described by Kimura,(15) at room temperature.(10,12) Farvid et als study measured neuropathy symptoms using the MNSI questionnaire, which generated total scores before and after intervention.(10) In Yaqub et als study, individual components of the Peripheral Neurology Symptom (PNS) score were used to assess somatic symptoms, autonomic symptoms and clinical signs.(12) In Fonseca et als study, symptoms and disability were assessed using the 6-item Neuropathy Total Symptom Score (NTSS-6) and the Neuropathy Disability Score, respectively.(11) All the studies analysed outcomes relating to VPTs or nerve conduction velocities

If neurological symptoms are present, injections may be needed every two months

doi:10.1056/NEJM199512213332507

For example, 8 weeks on followed by 4 weeks off, or 12 weeks on followed by 6 weeks off

We have to remember that during the first 1,000 days from conception to about 2 years of life there are many stages of development that only take place during a specific window of time