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Epigenetic status of argininosuccinate synthetase and argininosuccinate lyase modulates autophagy and cell death in glioblastoma

Eur J Of Endocrinology

Our comprehensive analysis of the mechanisms involved in Wnt signaling during I/R reveals that activation of the canonical Wnt pathway promotes organ recovery, while activation of the non-canonical Wnt pathways exacerbates injury

Although the mechanism is not fully elucidated, a general mode of action is that the gold agent accumulates in macrophages and consequently inhibits lysosomal enzymes as well as phagocytosis

For some individuals, this prolonged exposure can trigger symptoms, while for others, pregnancy may actually lead to symptom improvement due to immune system modulation