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10.1176/appi.ajp.158.8.1206 [DOI] [PubMed] [Google Scholar] Sharma H

Long-term follow-up information was available for 11 animals

This means that the results are permanent, provided you maintain a stable weight and a healthy lifestyle

The combination of energy pool depletion and metabolic dysfunction contributes to the severity of the disease and impacts the physiological health of the heart

Common (PN-related) Nausea Vomiting Mild fever or infusion discomfort Elevated BUN (from total nitrogen load) Hyperglycemia (PN carbohydrate component) Electrolyte abnormalities Proline-Specific Considerations Hyperprolinemia (rare without metabolic disorders) Symptoms may include: Neurologic changes Seizures (in genetic metabolic disorders) Cognitive alterations Amino-acid imbalance if hepatic metabolism impaired Severe (rare) Anaphylactoid reactions to amino-acid solutions Liver dysfunction with long-term high-dose PN Metabolic acidosis from improper PN formulation Refeeding syndrome (phosphate, potassium, magnesium shifts) Pregnancy & Breastfeeding Pregnancy Proline is a normal nutritional requirement and is safe when delivered as part of PN