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217 The use of a specific cell line to quantify the activation of the redox-sensitive transcription factor, nuclear factor (erythroid-derived 2)-like 2 (Nrf2), allowed to demonstrate that methotrexate also reduces the activation of the Nrf2-dependent intracellular redox signalling pathway

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The MnO 2 NPs, PVP, and PAA samples crushed into KBr pellets were analyzed by a Fourier-transform infrared (FT-IR) instrument (Vertex 70, Bruker), with a range of 4004,000 cm 1