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In periodontitis, the sustained stimulation from the subgingival biofilm and the hypoxic microenvironment of the periodontal pocket serve as key amplifiers of this loop

Unlike most thiols whose standard redox potential of the thioldisulfide couple ranges from 0.2 to 0.32 V, the value for ET is 0.06 V

Human trials are limited, long-term safety is unknown, and it has not been adopted in mainstream medicine

with acute liver failure

Defects in SDH subunits lead to succinate accumulation and oncometabolite-driven pseudohypoxia and are strongly linked to hereditary paragangliomas, pheochromocytomas and certain renal cell carcinomas, underscoring the essential role of complex II in metabolic and redox homeostasis 78,79