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These observations suggest that mitochondrial dysfunction can cause oxidative DNA damage and contributes to an altered epigenetic landscape to perpetuate radiation-induced instability [125]

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Because of the risks of addiction, abuse, misuse, overdose, and death, which can occur at any dosage or duration and persist over the course of therapy, [see WARNINGS], reserve opioid analgesics, including hydrocodone bitartrate and acetaminophen tablets, for use in patients for whom alternative treatment options are ineffective, not tolerated, or would be otherwise inadequate to provide sufficient management of pain

While basic screening can be performed in-house, standard laboratory methods often fail when dealing with rapid-leakage payloads, complex lipid matrices, or ultra-low drug concentrations

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