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3,5-diiodothyronine (T2) mediates short term effects of thyroid hormones and increases immediately basal metabolic rate
In fact, it has been demonstrated that ODC overexpression can be enough to promote prostate tumorigenesis, by altering mTOR/MAPK pathway among others [216]
doi: 10.1089/ars.2009.2484
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Indeed, while none of the phthalate metabolites displayed significant associations with fT3 in the presence of thyroid autoantibodies, in patients with no thyroid autoimmunity, all metabolites, except for MnBP, were inversely associated with fT3 [97]
