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doi: 10.1172/JCI115286

Because high xCT levels are associated with poor prognosis in a number of cancer types, including GBM 66 and triple-negative breast cancer 67 , the xCT transporter has been suggested as a therapeutic target for cancer 6769

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In the context of liver cancer, artemisinin has been demonstrated to reduce the protein expression of actin filament associated protein 1-like 2 (AFAP1L2) and reverses sorafenib resistance in specific liver cancer cell lines (Hep G2, Hep3B, MHCC-97 H, and Huh-7) [118]