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In the study by Sohaei et al
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In intracellular GSH synthesis, GCL can be the rate-limiting enzyme under the condition that all substrates are sufficiently present for the reactions, but the intracellular Cys concentration is much lower than those of Glu or Gly under physiological conditions, suggesting that the Cys availability is limiting for GSH synthesis [30,31]
doi: 10.1016/j.biopha.2024.116512 Summary Keywords cell death pathways, immune homeostasis, acute respiratory distress syndrome, ferroptosis, immune cytokines Citation Yao M, Liao J, Liu Z, Zhao W, Song S, Huang X and Wang Y (2025) Ferroptosis: a key driver and therapeutic target in the pathogenesis of acute respiratory distress syndrome
Nrf2 attenuates ferroptosis-mediated iir-ali by modulating tert and slc7a11
