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NO donors SNP and nitroglycerin have a long history of use in cardiovascular medicine for their vasodilatory effects [266,267] and other agents such as NO-releasing aspirin (NCX 4215) have also been observed to exert antithrombotic effects [268]

In primary cultured cortical neurons, nitric oxide exposure triggered dose-dependent mitochondrial fission and caused ultrastructural damage, which are associated with bioenergetic failure and increased ROS production

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Uddin et al., 2020