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When the platelets become activated, the released growth factors signal cells to migrate to the area to start healing damaged tissue and creating new blood vessels to improve circulation

Activated caspase-8 subsequently triggers caspase-3, leading to cell death

A liposome analysis of ferroptosis cells found that the accumulation of oxygenated AA-containing phosphatidylethanolamine species was associated with ALOX15 (78), which can shape adaptive immune response by inhibiting dendritic cell maturation and T cell helper cell 17 (TH17) differentiation via activating transcription factor NRF2 (79)

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doi: 10.3390/jcm13237086 86 ReaveyJJWalkerCMurrayAABrito-MutunayagamSSweeneySNicolMet al