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Structural and mutagenesis experiments revealed other important residues in the catalytic site like Glu146, Trp189, Trp125, Ser126, Thr221 and Arg127 [38-40, 59-60]

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Dosage: 200-500 mcg, 1-2 times daily via subcutaneous injection or daily oral capsules

Prevalence and trends in obesity among US adults, 1999-2008
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